Fuegians are the indigenous inhabitants of Tierra del Fuego, at the southern tip of South America. In English, the term originally referred to the Yaghan people of Tierra del Fuego. In Spanish, the term fueguino can refer to any person from the archipelago.

The indigenous Fuegians belonged to several tribes including the Ona (Selk'nam), Haush (Manek'enk), Yahgan (Yámana), and Alacaluf (Kawésqar). All of these tribes except the Selk'nam lived exclusively in coastal areas. The Yaghans and the Alacaluf traveled by canoes around the islands of the archipelago, while the coast dwelling Haush did not. The Selk'nam lived in the interior of Isla Grande de Tierra del Fuego and lived mainly by hunting guanacos. The Fuegian peoples spoke several distinct languages: both the Kawésqar language and the Yaghan language are considered language isolates, while the Selk'nams spoke a Chon language like the Tehuelches on the mainland.

When Europeans, Chileans and Argentines studied and settled on the islands in the mid-19th century, they brought with them diseases such as measles and smallpox for which the Fuegians had no immunity. The Fuegian population was devastated by the diseases, and their numbers were reduced from several thousand in the 19th century to hundreds in the 20th century. There are no full-blooded native Fuegians today; the last died in 1999.